Abstract
Cardiac and systemic pressor effects of PGD2 are variable in previous reports utilizing animals pretreated with pentobarbital paralysis and indomethacin. To test PGD2 effects without other drugs, 16 lambs were operated at <24 hours to ligate the ductus arteriosis and to place catheters in the aorta, pulmonary artery (PA), left atrium (LA) and inferior vena cava (IVC) and a flow transducer around the main PA. Vascular and cardiac effects of PGD2 at 0.1, 1, and 10 ug/kg × 1 min on aortic (SAP), PA and LA pressure (PAP, LAP), cardiac output (CO), heart rate (HR) and systemic and pulmonary vascular resistance (SVR, PVR) were studied during normoxia (N) and hypoxia (H) at ages 2.5, 11.4 and 25.5 days. PGD2 had age and oxygen related pulmonary vasodepressor effects. SAP and SVR increased from 5 to 20 mmHg (p<.05-.0001) at all doses and ages, under both N and H. HR and cardiac output fell at all doses. At 10 ug/kg/min:
PGD2 in intact unanesthetized lambs is a pressor and depresses cardiac function, perhaps reflexly. Neither age nor hypoxemia alters the response, unlike pulmonary vascular changes. Thus, interactions of PGD2 with other drugs alter cardiac and systemic circulatory resonses. Ill infants treated with combinations of barbiturates, indomethacin and/or paralytic agents may exhibit quite variable responses if also treated with PGD2.
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Drummond, W., Shrager, H., Dailey, W. et al. 360 CARDIAC DEPRESSANT EFFECTS OF PROSTAGLANDIN D2 (PGD2) IN AWAKE LAMBS 2 TO 32 DAYS OLD. Pediatr Res 19, 170 (1985). https://doi.org/10.1203/00006450-198504000-00390
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DOI: https://doi.org/10.1203/00006450-198504000-00390