Abstract
A monoclonal antibody HNK-1 (Leu 7) which recognizes a carbohydrate epitope on myelin associated glycoprotein (MAG) of nervous system has been shown to be present on cultured neurons, astrocytes, and oligodendrocytes. On neurons, the epitope is associated with de novo synthesized protein. Immunoblot analysis of lysates of cultured neurons reveals a family of glycoproteins spanning the molecular weight range 90 to 300 kilodaltons. Some of these neuronal surface glycoproteins participate in adhesion and neurite formation on certain immobilized substrates of growth within the extracellular matrix.
These data interpreted in the light of emerging information on neuronal adhesion molecules suggest that a family of glycoproteins, including MAG, act as cellular receptors for ligands within the extracellular environment.
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Riopelle, R., McGarry, R. & Roder, J. 309 IDENTIFICATION OF NOVEL SURFACE GLYCOPROTEINS SUBSERVING NEURONAL ADHESION IN DEVELOPMENT. Pediatr Res 19, 162 (1985). https://doi.org/10.1203/00006450-198504000-00339
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DOI: https://doi.org/10.1203/00006450-198504000-00339