Abstract
5 girls with true PP (4-8 years), demonstrating clinical signs of puberty, accelerated growth velocity, advanced bone age and pubertal LH/FSH levels of gonadotrophins, were treated with an intranasal spray of the LH-RH-analogue D-Ser (TBU)6-LH-RH-EA (Buserelin (B)) for 6 to 9 months. Therapy was started with 8×300 μg B/day intranasally (150 μg per puff into each nostril) for 2 weeks, followed by a maintenance dose of 3×300 μg/day.When spontaneous LH/FSH-secretion during the night (20 min.sampling intervals from 0 to 4 a.m.) before and 7 days after beginning of the treatment was compared, 2 girls showed a slight rise of median LH values (3.5 to 6.5 mIU/ml) and to others a decrease (18 to 9 mIU/ml). Only one had 2 spontaneous bursts of secretion that did not occur on B-therapy one week later. Whereas measurements of LH/FSH, E2 and testosterone after 1, 3, 6 and 9 months of B-treatment suggested continued suppression of the pituitary-gonadal axis, adrenal steroids (DHEA-S) did not change. Clinical signs of puberty were diminished or arrested, including the acceleration of skeletal maturation. Clinical or endocrinological escape phenomena were not observed. Intranasal application of B, therefore, compares favorably to other form of PP-therapy.
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Beyer, P., Eibs, HG., Schmidt-Aollwitzer, M. et al. 187 INTRANASAL TREATMENT OF PRECOCIOUS PUBERTY (PP) WITH A LONG-ACTING LH-RH-ANALOGUE. Pediatr Res 19, 634 (1985). https://doi.org/10.1203/00006450-198506000-00207
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DOI: https://doi.org/10.1203/00006450-198506000-00207
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