Abstract
We have investigated the degradation in vitro of calcitonin (CT) in human placental homogenates.
Mitochondrial fraction:placental tissue (0.5g) was homogenized and centrifuged for 1 hr at 13000 g.
Microsomal fraction: 5 g placental tissue was homogenized and centrifuged for 1 hr at 100000 g.
Human synthetic CT was incubated in 2 ml supernatant from each subcellular fraction at 4°, 20° and 37°C. Half-milliliter aliquotes were removed at intervals and immediately placed at -20°C. The CT values were measured by RIA.
After incubation with the microsomal fraction a degradation of only up to 0.9% was measured at both temperatures.
Conclusion: The capacity of the placenta to degrade calcitonin suggests its physiological importance for the calcium homeostasis during pregnancy.
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Balabanova, S., Bretzel, A., Wolf, A. et al. 160 DEGRADATION OF CALCITONIN BY HUMAN PLACENTA. Pediatr Res 19, 630 (1985). https://doi.org/10.1203/00006450-198506000-00180
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DOI: https://doi.org/10.1203/00006450-198506000-00180