Hypergastrinemia (↑ G), hypopepsinogenemia (↓ PG1) and gastric parietal cells autoantibodies (PCA) are considered as markers of atrophic gastritis which is a common complication in diabetic adults.
We investigated 32 insulin treated, non ketotic IDDM children (5 to 18 yrs old). without any gastro-intestinal symptom, with diabetes lasting from 2 to 130 mos. ↑ G, ↓ PGl and PCA have been found (single or in association) in 7/32 subjects (21,8%; 4 F-3 M).
In 5 of them a multiple perendoscopic gastric biopsy showed the histological pattern of a chronic superficial gastritis of antral and fundic mucosa in 2 females without correlation with a duration of diabetes.
- A chronic superficial gastritis may be present, in single cases of IDDM. yet in the pediatric age. It may be clinically silent but ↑ G ↓ PGl and PCA seem to be useful indicators.
- The pathogenesis and the possible relationship with the atrophic gastritis of diabetic adult are still to be clarified.
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de Angelis, G., Vanelli, M., De Luca, F. et al. 142 SUPERFICIAL CHRONIC GASTRITIS IN IDDM CHILDREN. Pediatr Res 19, 627 (1985). https://doi.org/10.1203/00006450-198506000-00162