Abstract
A Prolactin (PRL) hyper-response to TRH was described in IDDM children suggesting an alterated dopaminergic control. No changes in plasma renin activity (PRA) and aldosterone (A) plasma levels after Domperidone (DMP), a dopamine antagonist, were reported in adult healthy subjects. PRL, PRA and A levels were measured before and after i.v. DMP injection (10 mg/1.73 m2) in 10 IDDM insulin treated, normotensive, 2 hrs-recumbent, well controlled outpatients (10 to 19 years old).
The IDDM patients showed higher PRL responses than 11 control subjects of corresponding age (peak values: 112.7 ± 27.0 vs 45.4 ± 15.0 ng/ml; p < 0.02). The mean PRA values rose significantly (from 1.78 to 2.72 ng/ml/hr; p < 0.05) in 2/3 of the patients. The levels of A increased in all patients but not significantly.
The PRL hyper-responses to DMP in IDDM patients fit well with the hypothesis of abnormalities in dopaminergic tonus. Similar impairments seem to cause the unexpected PRA and A responses. The pathogenesis remains unknown.
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Vanelli, N., Terzi, C., Nori, G. et al. 141 PRL, PLASMA RENIN ACTIVITY AND ALDOSTERONE RESPONSE TO DOMPERIDONE IN IDDM CHILDREN. Pediatr Res 19, 627 (1985). https://doi.org/10.1203/00006450-198506000-00161
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DOI: https://doi.org/10.1203/00006450-198506000-00161