Abstract
The pregnancy-specific β1-glycoprotein or schwangerschaftsprotein (SP1) exists in two forms: SP1β is of trophoblastic origin and a glycoprotein with a molecular weight of 90,000 daltons. Together with a second protein which is not produced by the placenta it occurs in its second form SP1 . It is accepted that the rising concentration of SP1 during pregnancy reflects the growth of the placenta. - Is there a detectable release of SP1 also into the fetal circulation? To study this question, 9 human term placentae were investigated for 90 to 120 min by an in vitro perfused open placental lobule preparation. A radioimmunoassay measured SP1β and SPlα simultaneously. The sensitivity of determination was ≤ 2,5 ng/ml.
1. In the serum free fetal venous outflow, the concentrations of SP1 in all placentae were between 2,2 - 11,75 ng/ml.- The calculated release was 3,43 ng/min/g placenta (median; range 2,38 - 4,67).
2. The maternal venous concentrations of SP1 were between 175 - 862 ng/ml.- The calculated release was 830,4 ng/min/g placenta (median; range 621 - 1175,4).
Conclusion: The in vitro measurements show evidence for the release of SP1 into fetal circulation. With regards to fetal and maternal blood volume, there could exist different half-life times in mother and neonate.
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Henrichs, I., Benz, R., Wolf, A. et al. 106 SCHWANGERSCHAFTSPROTEIN (SP1): IN VITRO DELIVERY INTO MATERNAL AND FETAL CIRCULATION. Pediatr Res 19, 621 (1985). https://doi.org/10.1203/00006450-198506000-00126
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DOI: https://doi.org/10.1203/00006450-198506000-00126