Abstract
The availabilty of hGH allows successful treatment of idiopathic pituitary growth failure (GH deficiency). Final height (FH) is correlated with mid parent height, bone age (8A) deficit and the increase in height velocity. Adult height prediction (AHP) methods are based either on parental height or on clinical data. Therefore AHP may be useful to predict FH early in the course of the treatment of GH deficiency. Twenty one of our patients have already reached FH. 11 (8 M, 3 F) were classified as GH and gonadotrophin deficient (CD), 10 (9 M, 1 F) as isolated GH deficiency (ID). Five different AHP methods were used on retrospective data : Tanner's Target Height (TTH), CMP NANCY Target Height (NTH) (local population analysis) (*), Bayley-Pinneau (BP), Tanner-Whitehouse 1975 (TW), Tanner 1983 (TL). The calculations were done at the onset (0) and after 1 year of treatment (± 6 weeks) (+1) using a specific software running on a APPLE IIe 64K (*). FH was significantly correlated with all calculated predictions. The results (FH=AHP×A+B) are as follow:
The TL+1 AHP is the most closely correlated with FH (A=0.910, B=14, r=0.804, p < 0.01) for the ID subgroup. HP is less closely correlated with FH for the CD subgroup. This report supports the usefulness of TL method to predict FH in GH deficiency allowing a better follow-up of the growth response.
(*) Available on request.
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Leheup, B., Palandri, Y. & Pierson, M. 25 FINAL HEIGHT OF PATIENTS WITH IDIOPATHIC PITUITARY GROWTH FAILURE. CORRELATION WITH 5 ADULT HEIGHT PREDICTION METHODS AT THE ONSET AND AFTER ONE YEAR OF TREATMENT. Pediatr Res 19, 607 (1985). https://doi.org/10.1203/00006450-198506000-00045
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DOI: https://doi.org/10.1203/00006450-198506000-00045