Abstract
CF is a genetically linked multisystem disease which demonstrates alterations in humoral and cellular immune function. Defective PMN locomotion was recently described (NEJM 306:486, 1982) and may be implicated as a cause for increased pulmonare infections and complications. Other PMN function in children with CF during normal and active pulmonary exacerbations has not yet been examined. PMN functions of ten previously diagnosed CF patients (8-23 yrs; 6 M & 4F) were studied at a time of acute exacerbation of pulmonary disease and after recovery. Cells were tested for FMLP (N–Formyl–1–methionyl–1–1–eucyl–1–phenylalanine) stimulated aggregation and superoxide (O2−)production bacterial killing of S.aureus and adherence to nylon wool fiber. E.Coli endotoxin induced chemotaxis was also examined in the presence and absence of CF serum. In contrast to other investigators we found enhanced aggregation and chemotaxis (p<.01 and <.02) in CF patients (sick). No significant difference was found in PMN adherence, bacterial killing and O2− production. In addition, significance was not observed in CF PMN functions between the control and well phases.
Further studies are presently being conducted to elucidate additional differences involving peripheral PMN function as a marker for intrapulmonary complications and immunologic alterations in children with CF. In contrast to previous reports we identified enhanced PMN locomotion during acute exacerbations of pulmonary disease in children with CF.
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Griffith, J., Hicks, D., Wong, C. et al. 1771 ENHANCED PMN LOCOMOTION (AGGEEGATICN,CHEMOTAXIS) BUT NORMAL ADHERENCE BACIERIAL KILLING AND SUPEROXIDE PRODUCTION IN CHILDREN WITH CYSTIC FIBROSIS (CF). Pediatr Res 19, 406 (1985). https://doi.org/10.1203/00006450-198504000-01789
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DOI: https://doi.org/10.1203/00006450-198504000-01789