Abstract
Bladder washout studies (BWO) were done to localize the site of infection in 74 girls with recurrent urinary tract infections (UTIs). The UTIs were lower tract in 45 and upper tract in 29. The patients were divided into those on or off antibacterial prophylaxis (Rx) depending on whether they had received continuous antibacterial medication for more than 7 days preceding the index infection. According to these data (table), if Rx had no effect on the site of infection, 8 girls on Rx would be expected to have shown upper tract bacteriuria. The occurrence of renal bacteriuria in only 4 girls was probably not due to chance alone (X2 = 4.23; P < .05).
Vesicoureteral reflux was identified in 17 of the 68 girls on whom voiding cystourethrograms (VCU) were obtained. Eight of 17 girls (47%) with reflux had upper tract infections while 18 of 51 (35%) with no reflux had renal bacteriuria (X2=.75, P>.05). Six of the 17 girls with reflux were on Rx. Two of these had upper tract infections while 6 of 11 not on Rx had renal bacteriuria. More data are needed before drawing a conclusion about Rx and the site of infection in girls with reflux.
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Hellerstein, S., Savage, B. & Duggan, E. 1602 DOES ANTIBACTERIAL PROPHYLAXIS PREVENT PYELONEPHRITIS IN GIRLS WITH RECURRENT URINARY TRACT INFECTIONS?. Pediatr Res 19, 377 (1985). https://doi.org/10.1203/00006450-198504000-01626
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DOI: https://doi.org/10.1203/00006450-198504000-01626