Abstract
There is controversy in the literature regarding the effect of All on various components of the glomerular microcirculation. Experiments were performed on adult male Munich-Wistar rats paired according to weight (n=7 in each group). Following anesthesia, one animal in each pair was given an infusion of All at the rate of 0.5 μg/kg per min for 15-20 min while the other animal was given an identical volume of Ringer's lactate only. At the end of the infusion, the kidneys were fixed “in situ” with glutaraldehyde and injected with a silicone rubber compound. Following histological preparation of the tissue, measurements of glomerular tuft, arteriolar, and capillary diameters were performed with a caliper on projections of transparencies. All glomeruli chosen for examination were intact; none of the vessels were sectioned. The values are expressed in μm.
The results indicate no significant change in glomerular and capillary diameters, but a significant and similar change (33 and 32%, respectively) in afferent and efferent arteriolar diameters. Thus, All given in the amounts: specified, constricts to a similar extent the afferent and efferent vessels and has no effect on glomerular tuft and capillary diameters.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Goldsmith, D., Lu, YX., Pomrantz, A. et al. 1601 THE EFFECT OF ANGIOTENSIN II (All) ON GLOMERULAR VASCULATURE. Pediatr Res 19, 377 (1985). https://doi.org/10.1203/00006450-198504000-01625
Issue Date:
DOI: https://doi.org/10.1203/00006450-198504000-01625