1594 INAPPROPRIATELY LOW PLASMA CALCITRIOL (CD IN CHILDREN WITH NEPHROTIC SYNDROME (NS) AND NORMAL GLOMERULAR FILTRATION RATE(GFR)

Abstract

Although plasma CL levels in NS have been found to be low or normal, their interpretation remains ambiguous. To evaluate plasma CL in relation to its regulatory factors during both relapse (RL) and remission (RM), chi tdren with NS and normal GFR were studied. Data were compiled in 58 patients (39 males, 19 females) ages 2 to 20 yr (x 10.1) during 79 RL and 82 RM, Results were:

While, as expec+ed, in RM Ca correlated inversely (r = -0.04) and PTH directly (r = 0.12) with CL, in RL these correlations were direct (r = 0.48, p < 0.001) and inverse (r = -0.05), respectively. Serum albumin and CD correlated both directly with plasma CL; protelnuria correlated inversely better with CD (r = -0.26, p < 0.01) than with CL (r = -0.15, p <0.2>. We conclude that in nephrotic children, important abnormalities of mineral metabolism present in RL normalize during RM, daily protelnuria has a greater effect on plasma CD than on CL, and that circulating CL is normal in RL. The latter, however, is inappropriately low for the prevailing hypocalcemla and suggests inadequate synthesis of CL by the nephrotic kidney even with normal GFR.

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