Abstract
Protracted exposure to high oxygen tensions has been associated in preterm neonates with egress of leukocytes and alveolar macrophages into pulmonary interstitium and effluent obtained by bronchoalyeolar lavage. Pulmonary effluent serine elastase concentrations are increased in infants exposed to FiO2, >.4 Serum indomethacin concentrations of 10−5 to 10−7 molar have been associated with closure of the patent ductus arteriosus. We hypothesized.that indomethacin, a potent anti-inflammatory agent, might alter leukocyte chemotaxis in infants. Using modified Boyden chambers human term cord blood PMN leukocyte chemotaxis was altered (F=6.68,p=0.025) with linear attenuation (r= -0.77) to zymogen activated human serum. We speculate that indomethacin treatment of neonates may reduce oxygen induced inflammation through reducing leukocyte induced cytotoxic parenchymal lung damage and airways inflammation in addition to closing the patent ductus arteriosus. (HD 16292)
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Roberts, J., Jalowayski, A. & Merritt, T. 1021 REDUCTION OF CORD BLOOD POLYMORPHONUCLEAR (PMN) LEUKOCYTE CHEMOTAXIS BY INDOMETHACIN. Pediatr Res 19, 281 (1985). https://doi.org/10.1203/00006450-198504000-01051
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DOI: https://doi.org/10.1203/00006450-198504000-01051