REGIONAL CIRCULATORY RESPONSES IN 2–4 WEEK-OLD PIGLETS: EFFECTS OF FEEDING AND HEMORRHAGE (H)

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Abstract

Responses of the superior mesenteric(Mes), femoral(Fem) and renal(Ren) arterial blood flows(F) to feeding(Group I, n=20) and to feeding after a 15% blood volume H, (Group II, n=10) were examined in lightly anesthetized, artificially ventilated piglets. F were registered with electromagnetic probes pre- and postprandially for 2 hrs. EKG, heart rate and aortic pressure were continuously monitored. Regional vascular resistances(R) were calculated. Commercially formulated milk, 26 ml/kg, were given by gavage. Significant fall in pulse pressure(PP) occurred to H. After attaining a steady state following H; feeding protocol was carried out. Significant results (Mean±SE) are:

Postprandial Maximum Regional Circulatory Changes (4%, p < .05)

Significant changes in Group I started 15-30 min after feeding and at 45 min for Group II, both lasted the remainder of observation period. RenF and RenR changes were inconsistent. Group I responses indicate that regional F redistribution occurred with feeding favoring the Mes circulation. Following H, feeding increased MesF, FemF, PP and decreased FemR, MesR. These results suggest that piglets 2-4 wks of age are capable of overriding circulatory response to H during feeding. (Supported by NIH HL20864)

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