Abstract
EGF stimulates mitosis and enzymatic function of GI. Regional differences of EGF R in F GI might clarify the role that EGF plays in GI maturation. Plasma membrane bound EGF R of the 27d. F rabbit stomach(S), jejunum(J), ileum(I) and colon(C) were isolated and characterized by protein con., % recovery, DNA and 5'-nucleotidase. Optimal binding of 125I-EGF was obtained at 37° C, and pH 7.45 after 45 min. of incubation. All Scatchard plots were linear. (All data X̄±SEM, DNS-displacement not seen)
At 27d. there was very little EGF binding in the stomach while the highest density of EGF R was observed in the colon. EGF probably plays an important differential role in maturation of the fetal GI.
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Sadiq, F., Gunn, J., Cherhani, V. et al. DISTRIBUTION OF EPIDERMAL GROWTH FACTOR (EGF) RECEPTORS(R) IN THE FETAL(F) GASTROINTESTINAL TRACT (GI). Pediatr Res 18 (Suppl 4), 211 (1984). https://doi.org/10.1203/00006450-198404001-00706
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DOI: https://doi.org/10.1203/00006450-198404001-00706