Abstract
Receptor mediated role of EGF in fetal/neonatal L development and stimulating multiplication of B glial cells is well established. T4 enhances L maturation and CNS myelination. EGF receptor and T4 interactions were explored by examining the effect of HP and HT on S.B. of 125I-EGF to NB (<24 hours) rabbit LPM and BPM. NB were made HP by administering .05% PTU in drinking water at 24c of pregnancy. HT was achieved by administering 100ug/kg (I.M.) of T4 to the doe on 29th and 30th d. of gestation. LPM and BPM were isolated and characterized by protein % recovery, DNA and 5′-nucleotidase assay. S.B. of 125I-EGF to LPM or BPM was assessed at 37°C, pH 7.45 after 75′ of incubation. (ANOVA,*p<.01)
From these preliminary results we suggest that T4 status of the Id. NB may influence the development of B but not L EGF R.
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Sadiq, F., Devaskar, S., Chechani, V. et al. EFFECT OF HYPOTHYROIDISM (HP) AND HYPERTHYROIDISM (HT) ON 125I-EPIDERMAL GROWTH FACTOR (EGF) SPECIFIC BINDING (S.B.) TO NEWBORN (NB) LUNG (L) AND BRAIN (B) PLASMA MEMBRANE (PM). Pediatr Res 18 (Suppl 4), 176 (1984). https://doi.org/10.1203/00006450-198404001-00500
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DOI: https://doi.org/10.1203/00006450-198404001-00500