Abstract
We operated 17 newborn lambs at <24 hours to place indwelling catheters in the aorta (AO), pulmonary artery (PA), left atrium (LA) and inferior vena cava (IVC), a flow transducer around the main PA and to ligate the ductus arteriosus. The lambs were studied on alternate days during normoxia and hypoxia at age 2-3 days (n=9), 9-13 days (n=12), and >21 days (n=11) with .01,1, and 10 ug/kg PGD2 given in random order as a 1 minute infusion. We measured maximal change in systemic, pulmonary, and left atrial (SAP, PAP, and LAP) pressure, cardiac output (CO), and we calculated systemic (SVR) and pulmonary vascular resistance (PVR) and PVR/SVR. Decreased PVR was found only in young lambs with hypoxia +10ug/kg PGD2.
Increased PVR occurred with PGD2 during normoxia but not hypoxia in the older lambs. At each dose, with both N and H, SVR either increased or did not change. Thus, PGD2 might be useful in the immediate neonatal period for treatment of pulmonary hypertension, but very careful diagnosis and monitoring will be mandatory.
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Drummond, W., Shrager, H., Dalley, W. et al. AGE AND DOSE DEPENDENT PULMONARY VASCULAR CHANGES WITH PGD2 IN CHRONICALLY INSTRUMENTED LAMBS. Pediatr Res 18 (Suppl 4), 152 (1984). https://doi.org/10.1203/00006450-198404001-00354
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DOI: https://doi.org/10.1203/00006450-198404001-00354