Abstract
The effectiveness of vitamin E in prevention of oxygen induced tissue damage is likely related to the concentration at the site of action. The objective of this study was to evaluate the tissue disposition of E in the newborn following topical (TOP) as eye drops, intravenous (IV) and intramuscular (IM) E (100 mg/kg). TOP E had no significant effect on serum or tissue levels of E. Peak E concentration in the liver and lung following IV was observed within 5 hrs; However maximal sustained retinal E levels following IV administration were not observed until 40 hrs. IM administration produced a significant increase in retinal E within 16 hrs. Peak values for serum, tissue (mcg/g tissue) and retinal (mcg/g protein) E are:
We conclude (1) IM administration produced a more rapid and sustained increase in retinal vitamin E levels in comparison to IV administration; (2) whereas IV administration produced higher levels of vitamin E in the nontarget organs. (Supported by NIH EY04990).
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Bhat, R., Braun, R. RETINAL AND TISSUE VITAMIN E KINETICS IN THE NEWBORN KITTEN FOLLOWING VITAMIN E ADMINISTRATION. Pediatr Res 18 (Suppl 4), 149 (1984). https://doi.org/10.1203/00006450-198404001-00339
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DOI: https://doi.org/10.1203/00006450-198404001-00339