Abstract
Plasma levels of lipase (LPL, HL) and free fatty acids (FFA) were measured in 21 infants (gest. age 26-35 wks) aged 1-8 days, maintained on total parenteral nutrition with heparin (1 U/ml) and given 1, 2 and 3 g IL/kg/day (over 15 h) on day 1, 2 and 3, respectively. Blood samples were drawn before and at the end of IL administration.
HL, determined with anti-human HL antibody was 50% and 27% of total activity in R and NR, respectively, both before and after IL infusion. There were no differences in BW or gest. age between R and NR. In all infants there was a significant correlation between FFA and LPL activity (r = .749, p < .001). The increase in HL and LPL activity in infants given increasing doses of IL with continuous heparin may be due to stabilization of enzyme activity and/or to enhancement of the effect of heparin on enzyme release. The resulting high levels of FFA (>2.0 mmol/1) warrant caution in the use of large amounts of IL in association with continuous low level heparin. (Supported by NIH grants HD-15631 and RR-00240).
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Berkow, S., Spear, M., Gutman, A. et al. LIPID CLEARING IN PREMATURE INFANTS. RESPONSE TO INCREASING DOSES OF INTRALIPID (IL): I-CIRCULATING LIPOPROTEIN LIPASE(LPL) AND HEPATIC LIPASE(HL). Pediatr Res 18 (Suppl 4), 136 (1984). https://doi.org/10.1203/00006450-198404001-00256
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DOI: https://doi.org/10.1203/00006450-198404001-00256