LIPID CLEARING IN PREMATURE INFANTS. RESPONSE TO INCREASING DOSES OF INTRALIPID(IL): II-FREE FATTY ACIDS(FFA), TRIGLYCERIDES(TG) AND CHOLESTEROL(CHOL)

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Abstract

Plasma levels of FFA, TG and CHOL were measured in 21 premature infants (gest. age 26-35 wks.), aged 1-8 days, maintained on total parenteral nutrition with heparin (1 U/ml) and given 1, 2 and 3 g IL/kg/day (over 15 h) on day 1, 2 and 3 respectively. Blood samples were drawn before and at the end of IL administration.

In all infants there was a transient, dose dependent increase in TG and a cumulative increase in CHOL. A significant positive correlation between FFA and TG levels (r = 0.65, p<.001) at 15 hr of TG infusion suggests that plasma TG at that time is a mixture of IL and VLDL newly synthesized from the released free fatty acids. A significant positive correlation between FFA and CHOL levels (r = 0.58, p<.001) at 15 hr of TG infusion suggests that the CHOL is also newly synthesized from FFA-derived acetyl-CoA. During the following 9 hours, the removal of the excess TG was adequate, but the cumulative increase in CHOL necessitates further study. (Supported by NIH grants HD-15631 and RR-00240).

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