Abstract
Effects of exogenous surfactant (S-TA, Fujiwara) on hemodynamics and organ blood flow were studied in prematurely delivered baboons (76% term). Cardiac output (CO) and organ blood flow were measured before, 2 h and 7 h after surfactant using Sr85, Cr51 and Ce141, respectively. Colloid osmotic pressure (COP) was measured using osmometer (mm Hg). Diagnosis of PDA was confirmed by one shot angiography and at autopsy. Data from 3 control (A) and 2 S-TA treated (B) baboons are shown below.
Organ blood is expressed as ml/min/gram (M±S.E). Ductal size was larger in surfactant treated baboons than in controls (3.5 mm vs 2.0 mm). This preliminary data suggest that (1) transient increase in lung blood flow seen after TA surfactant is secondary to large L to R shunt thru the PDA; (2) progressive increase in renal blood flow may be secondary to decrease in renal resistance; (3) colloid osmotic pressure increased in surfactant treated in comparision to control.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
John, E., Bhat, R., Maeta, H. et al. HEMODYNAMIC CHANGES FOLLOWING ARTIFICIAL SURFACTANT THERAPY: A CONTROLLED STUDY. Pediatr Res 18 (Suppl 4), 124 (1984). https://doi.org/10.1203/00006450-198404001-00185
Issue Date:
DOI: https://doi.org/10.1203/00006450-198404001-00185