Abstract
We studied 6 chronically instrumented newborn lambs during normoxia (N) and hypoxia (H) on alternating days during infusion of isoproteronol (I) from .062 to 2.5 mcg/kg/min while measuring PAP, LAP, SAP, pulmonary flow (QP) heart rate (HR) and blood gases. Pulmonary (PVR) and systemic vascular resistance (SVR) and PVR/SVR were calculated. Infusion during N resulted in decreased SAP, PVR, SVR and increased HR, QP, and PVR/SVR. During H+I compared to N base, SAP, and SVR decreased and PAP, PVR, HR, QP, and PVR/SVR increased. QP increased significantly during H alone, and did not increase further with I infusion. Changes from N base to H base were not increased further when H+I was compared to H base except for HR which rose from 271±8 to 320±19 ml/kg/min.
No arrhythmias occurred with I, but one lamb required resuscitation when QP fell to zero and respiration ceased during H+I at 2.5 mcg/kg/min. A significant persistent metabolic acidosis occurred during both H and N and continued into the recovery periods. Neonates may not benefit from isoproteronol infusion under hypoxic conditions.
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Hagen, E., Drummond, W., Shrager, H. et al. RESPONSE OF NEWBORN LAMB TO ISOPROTERONOL INFUSION. Pediatr Res 18 (Suppl 4), 122 (1984). https://doi.org/10.1203/00006450-198404001-00176
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DOI: https://doi.org/10.1203/00006450-198404001-00176