Abstract
Because pediatric studies of verapamil (V) are few, the cardiovascular effects of the clinical dose range were examined in 1 day and 2 week old anesthetized swine: 100 or 300 ug/kg verapamil (V) was infused iv over 2 min. Blood pressure (BP), LV dP/dt max, heart rate (HR) and phasic superior mesenteric (Mes), renal (Ren) and femoral (Fem) arterial blood flows (F) were recorded and vascular resistances (R) calculated. Maximum responses (mean % ± SE) occurred at the end of the infusion:
HR remained increased 30 min after 100 ug/kg V in 2 week olds. At 30 min after 300 ug/kg V, there were still decreases in BP in all, and LV dP/dt, HR and FemF in day olds. HR and FemF decreased 3-30 and 10-30 min, respectively, after 300 ug/kg V in 2 week olds. The results indicate that V has both age- and dose-dependent cardiovascular effects in newborn swine and suggest that V should be used with caution in infants.
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Gootman, N., Buckley, B., Kaplan, N. et al. NEONATAL CARDIOVASCULAR EFFECTS OF VERAPAMIL. Pediatr Res 18 (Suppl 4), 122 (1984). https://doi.org/10.1203/00006450-198404001-00175
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DOI: https://doi.org/10.1203/00006450-198404001-00175