Abstract
Measurement of plasma arginine vasopressin in the differential diagnosis of polyuria. In children and adolescents (1-18 y, n:65) a linear correlation between plasma arginine vasopressin (AVP) and plasma osmolality (Posm), as well as between AVP and urine osmolality (Uosm) was observed. In polyuric patients AVP was measured following osmotic stimulation. After 12-16 h of water deprivation in control children AVP rose to 7.7±3.2 pg/ml, Posm to 296±9.0 and max. Uosm to 1024±124 mosmol/kg (x̄±SD, n:12). In patients with various tubular disorders impaired renal concentration was obtained (max. Uosm 370±145, Posm 302±11.6 mosmol/kg, n:7). AVP was higher as compared to the control group (14.0±6.8 pg/ml). In 6 patients with central diabetes insipidus AVP was within the low normal range or below the detection limit of 0.8 pg/ml. By means of an infusion of hypertonic saline solution (5% NaCl, 0.04 ml/kg per min for 2 h) a partial defect in AVP release was separated from a complete one.Whereas in the complete form of central diabetes insipidus also at high Posm (>310 mosmol/kg) AVP was undetectable, it was measurable in the partial form, but inadequately low for concurrent Posm. Measurement of AVP during osmotic stimulation is of significance in the differential diagnosis of polyuria.
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Rascher, W., Schärer, K. & Heinrich, U. Measurement of plasma arginine vasopressin in the differential diagnosis of polyuria. Pediatr Res 18, 1214 (1984). https://doi.org/10.1203/00006450-198411000-00080
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DOI: https://doi.org/10.1203/00006450-198411000-00080