Abstract
Groups of 8 lambs were delivered at 122, 135 or 146 days (d) gestational age (GA) and ventilated. Lambs at 122 d were treated with natural sheep surfactant (NS). Mean blood gas values and ventilator settings were similar for all groups. The lambs at 146 d required lower peak inspiratory pressures (PIP) to normalize pCO2 values relative to the other lambs (15 vs 24 cm H2O). To control for this variable, 4 lambs at 146 d were ventilated at 25 cm H2O PIP with added CO2 to normalize pCO2. The exit from the airways of 125I-albumin added to fetal lung fluid at delivery, the entrance into the airways of 131I-albumin given by vascular injection, the protein in alveolar washes (AW), and % recovery of labeled albumin in lung tissue (corrected for blood volume) were measured after 3 hr of ventilation.
The amount of 125I that left the alveoli increased, the amount of 131I that entered the alveoli increased, and total protein increased as GA decreased (p values <0.05, ANOVA). There is an increasing protein leak with decreasing GA in ventilated lambs that is independent of NS treatment or the PIP required to ventilate the lambs.
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Jobe, A., Ikegami, M., Jacobs, H. et al. INCREASED LUNG PROTEIN PERMEABILITY OF PREMATURELY DELIVERED AND VENTILATED LAMBS. Pediatr Res 18 (Suppl 4), 394 (1984). https://doi.org/10.1203/00006450-198404001-01808
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DOI: https://doi.org/10.1203/00006450-198404001-01808