Abstract
During 1 year, 77 infants of gestation < 37 wks survived severe asphyxia, primary apnea or seizures. Sequential brain ultrasound scans were done to determine the incidence and evolution of hemorrhage in the germinal layer (GLH), ventricles (IVH) or cerebral white matter (ICH) and ischemic periventricular leukomalacia (PVL).
Groups 1 and 2 (vs 3) had an increased incidence of GLH (p<0.05) and IVH (p<0.01). ICH and major IVH occurred most frequently in Group 1 (vs 2 & 3, p<0.05). PVL diagnosed by white matter echogenicity or cysts occurred with equal frequency across all gestational ages. All cases of IVH and ICH and all but 2 cases of GLH were diagnosed within 14 days of age. PVL superolateral to the ventricle developed later (up to age 67 days) and would have been missed by early scanning. The data suggest that all high risk cases should have additional scans 3 to 6 wks after the insult.
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Zarfin, Y., Pape, K., Nwaesei, C. et al. HEMORRHAGIC AND ISCHEMIC LESIONS IN THE PRETERM BRAIN. Pediatr Res 18 (Suppl 4), 381 (1984). https://doi.org/10.1203/00006450-198404001-01728
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DOI: https://doi.org/10.1203/00006450-198404001-01728