Abstract
Twelve premature twin lambs delivered by C-section at 133-136 days gestational age were supported for 3 hrs. on an F1 O2= 1.0 on either HFO at 900 breaths/min. or CMV at 20 - 30 breaths/min. Average ± SE blood gas values were similar at sacrifice, but the HFO group required a higher MAP (16 ± 0.78 vs. 13.3 ± 1.43 on CMV). Both groups had similar degrees of epithelial necrosis, hyaline membrane formation and equal disruption of alveolar permeability as evidenced by bidirectional leak of labelled albumin and alveolar wash proteins. The HFO animals had a smaller alveolar pool of endogenous phosphatydyleholine (PC) and larger tissue associated exogenous H3 natural surfactant tracer (H3 -NS) which may represent a decrease in initial secretion of surfactant and/or a stimulation of reuptake in this group. This study failed to prove the superiority of HFO over CMV suggested by our previous studies in a different animal model both in terms of decreasing barotrauma and improving gas exchange and raises important questions with regards to its effect on surfactant turnover.
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Solimano, A., Bryan, A., Jobe, A. et al. HIGH FREQUENCY OSCILLATION (HFO) VS. CONVENTIONAL MECHANICAL VENTILATION BAROTRAUMA, SURFACTANT AND SURFACE TENSLOE IN PREMATURE LAMBS. Pediatr Res 18 (Suppl 4), 348 (1984). https://doi.org/10.1203/00006450-198404001-01529
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DOI: https://doi.org/10.1203/00006450-198404001-01529
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