We studied the blood flow (BF) to and vascular resistance (VR) of vital tissues in 7 anesthetized newborn lambs in response to hypovolemic hypotension. BF was measured with radioactive microspheres injected into the left ventricle; blood pressure (BP) and arterial blood samples were taken from axillary arteries. BP was reduced by phlebotomy in three steps in each lamb.
Calculated VR decreased in the heart, brain and adrenals and increased in the kidney and spleen. However, VR in the small intestine was not changed with hypotension. These data indicate that in the neonatal lamb the vascular response of the intestine to hypotension may be different than that of other abdominal visceral organs. Supported by USUHS grants C08631 and C08626.
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O'Neill, J., Golden, S. & Alden, E. REGIONAL DISTRIBUTION OF BLOOD FLOW WITH HYPOVOLEMIC HYPOTENSION IN THE NEONATAL LAMB. Pediatr Res 18, 322 (1984). https://doi.org/10.1203/00006450-198404001-01376