Abstract
To evaluate the effect of linolenic acid supplementation on linoleic-arachidonic conversion during PN, preterm AGA infants were randomized to receive Liposyn 20% (group 1, N = 8, 0.5% linolenate) or Modified Liposyn 20% (group 2, N = 8, 5% linolenate). Mean birth weight (1470, 1350 gm in groups 1 and 2, respectively), gestation (30.9, 30.8 weeks), age at the beginning of the study (4.6 days), daily nutrient intake during the study (45, 48 cal/kg) and clinical features were similar. 0.68 gm/kg of lipid was infused daily for 5 days. Blood sampling was done before the study began (4 ± 1 days, #1), at 6 ± 1 (#2), and 8 ± 1 (#3) days of age. The results (mean, SD) expressed as weight % of plasma phospholipid are outlined.
Plasma linoleate was similar in both groups. Although baseline (#1) arachidonate is greater (P <.05) in group 1, no significant differences are noted thereafter. Triene/tetraene ratio remains normal throughout the study. Thus linolenate supplementation, at 5% of the total lipid intake does not inhibit linoleate arachidonate conversion or adversely affect essential fatty acid status.
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Zee, P., Cooke, R. & Yeh, YY. LINOLENATE SUPPLEMENTATION AND LINOLEATE-ARACHIDONATE CONVERSION. Pediatr Res 18 (Suppl 4), 316 (1984). https://doi.org/10.1203/00006450-198404001-01341
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DOI: https://doi.org/10.1203/00006450-198404001-01341