Abstract
Rapid changes occur in essential fatty acid status (EFAS) during fat-free parenteral nutrition (Pediatr Res 4:309A, 1983). We therefore evaluated the effects of IV Liposyn 20% administration on EFAS and compared them to the control group (group 1). Infants received either 0.34 gm (group 2) or 0.68 gm (group 3)/kg of lipid daily for 5 days providing 2% or 4% of the estimated caloric requirement (120 cal/kg/day) in the form of linoleic acid. Mean birth weight (1410, 1400, and 1470 gm in groups 1, 2, and 3, respectively), gestation (31.2, 31.4, and 30.9), daily caloric intake during the study (51.2, 50.2, and 49.3 cal/kg) and clinical features were similar. EFAS was assessed at 4 ± 1 (#1, before starting PN), at 6 ± 1 (#2), and 8 ± 1 (#3) days of age. Triene/tetraene ratio (T/T; mean, SD) is expressed as weight % of fatty acid in plasma phospholipids. The results are outlined.
Baseline (#1) T/T ratio is similar in all groups. T/T ratios in groups 2 and 3 do not change significantly and remain lower than in group 1 (P <.01, 2-way ANOVA). We conclude that 1) IV lipids prevent rapid changes occurring in EFAS during PN; 2) 2% is as effective as 4% linoleate in maintaining baseline T/T ratio.
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Cooke, R., Zee, P. & Yeh, YY. INTRAVENOUS LIPID ADMINISTRATION IN THE PREMATURE INFANT. 1. EFFECT ON ESSENTIAL FATTY ACID STATUS (EFAS). Pediatr Res 18 (Suppl 4), 316 (1984). https://doi.org/10.1203/00006450-198404001-01340
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DOI: https://doi.org/10.1203/00006450-198404001-01340