Abstract
Unmonitored use of heparinized parenteral solutions with the altered heparin metabolism, indwelling catheters and paradoxical hypercoagulable status of newborns is of particular concern. Neoates (n = 164) with birthweight (BW) from 500 to 3500 gms were studied. Only central intravascular solutions were heparinized (100 units/100 ml). Coagulability (Co) was determined as the slope (units/sec) of thrombin generation curve (Sonoclot ); The daily dose of H and plasma H level (0.1 unit/ml ≅ a PTT of 60 secs) and Co were measured. Serial mean daily values of Co for each group (SD ± 18%) are:
The ranges of mean H level (units/ml) and dose (units/kg) for each group are; I: 0.03 - 0.11; dose: 4.4 - 6.6. II: 0.027 - 0.053; dose: 4.3 - 6.7. III. 0 - 0.05; dose: 1.4 - 5.5. IV: 0 - 0.05; 1 - 5.0. V: 0.02 - 0.06; dose: 2 - 5.0. VI: 0.02 - 0.06; dose: 1 - 5.0.These data confirm a continuing hypercoaguable status. Normal values of Co (20 - 25) were only achieved in Gr I and relate to the higher H dosage and higher H level (0.1). To provide a less coagulable status Co levels are used to adjust both dosage/kg and the H level.
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Bhutani, V., Abbasi, S., Grous, M. et al. EVALUATION OF NEONATAL HYPERCOAGULABILITY AND ROUTINE HEPARINIZED INFUSIONS. Pediatr Res 18 (Suppl 4), 312 (1984). https://doi.org/10.1203/00006450-198404001-01315
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DOI: https://doi.org/10.1203/00006450-198404001-01315