GGTP is a membrane enzyme facilitating amino acid transport into cells. We have studied the specific activity of the enzyme in young, growing rats rendered uremic by 7/8 nephrectomy. Results were compared to control animals fed either isocaloric diets (PC) or ad libitum diets (AC). Tissues were assayed for GGTP activity after 21 days of controlled feeding. Tissues included kidney, liver, intestinal mucosa and leukocytes. The following table summarizes the results (mean ± S.D.):
The results demonstrate abnormally low GGTP in leukocytes of uremic rats. Kidney GGTP was higher than control values possibly on the basis of renal tubular injury. Malnutrition does not appear to significantly influence GGTP activity.