Abstract
AGP (orosomucoid) and CRP provide help in the diagnosis of bacterial infection in neonates. Their use in following the course of systemic neonatal infection was evaluated in 49 neonates (GA:mean35 weeks,range 26-41w;BW:mean2206g.,range 880-4400) using sequential, quantitative (nephelometric) determinations. Early infection (<6 days of age) was observed in 28 patients:late in 21 patients. The outcome was favorable in all but 8 infants. Initial AGP and CRP concentrations were (mean ± 1SD)133 ± 75 mg/dl and 8.4 ± 7.5 mg/dl. After 5-6 days of favorable evolution, CRP decreased to a mean of 4.7 mg/dl (< 0.5-17.5) and after 13-16 days to 2.0 mg/dl (<0.5-18.8). Serum AGP increased to 142 ± 73 mg/dl and then decreased to 116 ± 75 mg/dl after the same time intervals. Higher values were associated with meningitis. During the 3rd week, no CRP value was above 0.8 mg/dl, and AGP was normal at 86 ± 40 mg/dl. The normalization of serum AGP was similar to clinical healing.In contrast, a dramatic increase of CRP was observed in patients with a bad outcome, especially 3 patients who died and two with profound neurologic damage. In one patient with arthritis the recurrence of symptoms was observed with a re-elevation of serum AGP while serum CRP was normal. The data confirm the abnormal elevation of serum CRP and AGP in neonates with bacterial infection. They suggest that CRP is a reflection of the efficacy of the treatment and that the normallization of serum AGP coincides with recovery.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sann, L., Bienvenu, F., Bienvenu, J. et al. α-ACID GLYCOPROTEIN (AGP) AND C-REACTIVE PROTEIN (CRP) IN THE EVOLUTION OF BACTERIAL INFECTION OF NEONATES. Pediatr Res 18 (Suppl 4), 285 (1984). https://doi.org/10.1203/00006450-198404001-01152
Issue Date:
DOI: https://doi.org/10.1203/00006450-198404001-01152