Abstract
Cotton rats receiving IVIG were challenged intranasally 24 hrs later with RSV. These animals and concomitantly infected controls were sacrificed 4 days later. Animals treated with IVIG showed a 100- to 1000-fold reduction in pulmonary virus compared to controls, and a lesser, though highly significant reduction in nasal virus. Cross-homogenization experiments showed the reduced viral titers to be in vivo phenomena, rather than in vitro viral neutralization occurring at the time of tissue homogenization. Several lots of IVIG, all with high neutralizing titers against RSV, were tested in cotton rats, with similar results. Protection was dose-dependent, and was maximal when circulating antibody titers were greater than 1:250. Cotton rats previously infected with RSV were given IVIG to determine if it might alter the course of infection. Animals receiving IVIG as little as 3 hrs prior to sacrifice showed highly significant reductions in pulmonary and nasal viral titers, with the effect greatest in the lungs (geometric mean reduction of over 100-fold). Cross-homogenization experiments showed the reduction to be bona fide in vivo viral neutralization, rather than in vitro artifact. Histologic studies of lungs of IVIG treated animals showed no histopathological abnormalities.
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Prince, G., Hemming, V., Horswood, R. et al. INTRAVENOUS IMMUNE SERUM GLOBULIN (IVIG) FOR PROPHYLAXIS AND TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS (RSV)) INFECTIONE IN THE COTTON RAT. Pediatr Res 18 (Suppl 4), 284 (1984). https://doi.org/10.1203/00006450-198404001-01144
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DOI: https://doi.org/10.1203/00006450-198404001-01144
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