Abstract
AIDS, characterized by T-cell dysfunction, has been reported in H. However, many of the infections in AIDS may reflect neutrophil (PMN) dysfunction. 15 healthy adults (Gp 1), 18 adult H patients (Gp 2) and 5 adult AIDS patients (Gp 3) were studied. T-cells (Leu-1), helper T-cells (Leu-3) and suppressor T-cells (Leu-2) were determined. PMN chemotaxis (CTX) was measured with an agarose technique. PMN adherence (ADH) was measured with a nylon wool column assay. Results were expressed as means ± SEM percent of lymphocytes or migrating neutrophils.
These results confirm similiar abnormal T-cell subsets in H and AIDS. PMN ADH in H patients and PMN ADH and CTX in AIDS patients were normal. However, CTX was impaired in 12 of 16 H patients studied. Incubating control cells with sera from H and AIDS patients did not affect CTX.
Although H and AIDS have similiar T-cell abnormalities, the normal PMN CTX in AIDS is in contrast to the decreased CTX in H patients. The immune dysfunction seen in H appears to have pathogenetic factors in addition to those that cause AIDS.
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Lewis, J., Church, J., Gomperts, E. et al. T LYMPHOCYTE SUBSETS AND NEUTROPHIL CHEMOTAXIS AND ADHERENCE IN HEMOPHILIA (H) AND ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS). Pediatr Res 18 (Suppl 4), 260 (1984). https://doi.org/10.1203/00006450-198404001-01000
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DOI: https://doi.org/10.1203/00006450-198404001-01000