Summary: The effects of fluorocarbon ventilation on cardiopulmonary function were studied in 8 preterm lambs, 132–136 days gestation. After mechanical ventilation with 100% oxygen (control period), the lambs were ventilated with fluorocarbon (P1O2 = 622 torr). The liquid was then removed from their lungs and gas ventilation resumed (recovery period). During normothermic liquid breathing the alveolar-arterial O2 gradient (A-a DO2) decreased (P <0.01) from control by 154 torr and remained decreased (P <0.05); PaO2 increased 50% (P <0.05); and PaCO2 decreased 29% (P <0.01) as compared to control values. The change in A-a DO2 and PaO2 before and after liquid ventilation was correlated (r = 0.79 and P <0.01) with control CL. There was a gradual decrease (P <0.01) in mean arterial pressure from 62 ± 5.4 torr (control) to 53.1 ± 9.3 torr (recovery); however, there were no significant alterations in mean central venous pressure, heart rate, or mean electrical axis.
Speculation: These data demonstrate an imporvement in gas exchange and dynamic lung compliance in preterm lambs after liquid fluorocarbon ventilation. Regression lambs with the lowest initial lung compliance. Futhermore, the secondary effects of improved ventilation and pulmonary blood flow, in the long run could facilitate surfactant synthesis.
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Shaffer, T., Douglas, P., Lowe, C. et al. THE EFFECTS OF LIQUID VENTILATION ON CARDIOPULMONARY FUNCTION IN PRETERM LAMBS. Pediatr Res 17, 303–306 (1983). https://doi.org/10.1203/00006450-198304000-00017
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