Abstract
Summary: Cardiopulmonary function was evaluated in very preterm lambs (106 ± 0.7 S.E. days gestation, 1.66 ± 0.12 S.E. kg birth weight) during fluorocarbon ventilation. Lambs were delivered by cesarean section after epidural anesthesia. Indwelling arterial, venous, and tracheal cannulae were placed before clamping the cord. Lambs were then mechanically ventilated with oxygenated fluorocarbon for approximately 2 h. During this period it was possible to maintain adequate gas exchange and stable cardiac function. Transpulmonary pressure, liquid flow, and tidal volume tracings enabled determination of lung compliance, CL = 0.58 ± 0.12 S.E. ml · cmH2O · kg-1, inspiratory resistance, R1 = 3600 ± 604 S.E. cmH2O · liter−1 · sec−1, and expiratory resistance, RE = 4034 ± 2183 S.E. cmH2O/liter/sec. Lung compliance of the 106-day-old fluorocarbon-filled lung is similar to the more mature 138-143-day-old air-filled lung in preterm lambs. Based on the data presented herein we have extended the viability of the preterm lamb to the limit of pulmonary capillary development rather than that of the pulmonary surfactant system.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shaffer, T., Tran, N., Bhutani, V. et al. Cardiopulmonary Function in Very Preterm Lambs during Liquid Ventilation. Pediatr Res 17, 680–684 (1983). https://doi.org/10.1203/00006450-198308000-00016
Issue Date:
DOI: https://doi.org/10.1203/00006450-198308000-00016
This article is cited by
-
Total liquid ventilation in an ovine model of extreme prematurity: a randomized study
Pediatric Research (2023)
-
Liquid Ventilation in the Management of Preterm Infants
Current Stem Cell Reports (2021)
-
An out of body experience
Nature (2002)
-
Liquid ventilation: An alternative ventilation strategy for management of neonatal respiratory distress
European Journal of Pediatrics (1996)