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Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat

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Summary: Infant rats infected with influenza A virus, Sendai (parainfluenza 1) virus or rat coronavirus were used to determine whether viral infection increases the intensity of nasal colonization with Haemophilus influenzae type b (HIB). Intranasal inoculation of HIB in rats previously infected with each of these viruses resulted in nasal HIB titers at least 100-fold higher than those for controls during the first 2 wk after HIB inoculation, and as much as 10,000-fold higher during the first week. Children with cough, sneezing, or rhinorrhea could be effective disseminators of HIB if they were as heavily and persistently colonized as these virus-infected animals.

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Correspondence to Richard H Michaels.

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Michaels, R., Myerowitz, R. Viral Enhancement of Nasal Colonization with Haemophilus influenzae Type b in the Infant Rat. Pediatr Res 17, 472–473 (1983). https://doi.org/10.1203/00006450-198306000-00009

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