Abstract
Dietary cholesterol(DC), P/S ratios, and total fat (TF, as a % of calories) were altered during two 3 month diet(D) periods to assess effects of D on plasma low density lipoprotein cholesterol (LDLC) in 11 normal(N) children(CH), and in 12 CH heterozygous for familial hypercholesterolemia(FH). The baseline ad lib D(<350 mg DC, TF 40%, P/S 0.7) was compared to a therapeutic(T) D, (<150 mg DC, TF 35%, P/S 1.0), and subsequently to a DC rich,lower P/S D (>450 mg DC, TF 40%, P/S 0.6). Adherence to D and nutrient intakes (NI) were assessed monthly using a 7 day D diary. General food patterns were retained; targeted NI levels were reached by substitutions with commercially available fat-altered foods. The number(n) of N and FH CH by age-,race, and sex-specific LDLC percentile distributions during the D periods were as follows:
The TD shifted LDLC in N CH downward from levels on ad lib D, moving the LDLC mode to the 50th percentile, while DC rich D elevated LDLC, with all 11 N CH at or above the 75th percentile. In FH CH, LDLC generally remained >the 95th percentile irrespective of D. TD have major utility in N CH, many of whom acquire elevated LDLC on ad lib and DC rich, low P/S D.
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Gartside, P., Stein, E., Shapero, J. et al. 552 ALTERATION OF LOW DENSITY LIPOPROTEIN CHOLESTEROL BY CHANGES IN DIETARY CHOLESTEROL, TOTAL FAT, AND P/S IN NORMAL AND HYPERCHOLESTEROLEMIC CHILDREN. Pediatr Res 15 (Suppl 4), 532 (1981). https://doi.org/10.1203/00006450-198104001-00565
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DOI: https://doi.org/10.1203/00006450-198104001-00565