Abstract
Basal acid output (BAO) and pentagastrin (6 μg/kg SC) stimulated maximal acid output (MAO) were measured in 42 normal (NL) children (age range 2-144 mo; x = 19.4 mo). Similar measurements were made in 16 patients with PUD (age range 3-216 mo; x = 96.6 mo) including 7 evaluated both before and after 6 weeks of therapy. BAO and MAO were calculated by conventional technique with hydrogen ion concentration determined by titration to pH 7.0. The BAO and MAO in the NL children were (x ± SEM) 0.17 ± 0.22 meq/kg/hr and 1.38 ± 0.61 meq/kg/hr respectively. Although older heavier children produced more total acid than younger smaller ones, on a per kg basis no correlation was found between acid output (BAO/MAO) and increasing weight. Neither was there a correlation found between acid output (BAO/MAO; meq/kg/hr) and either height, age or sex. There was no significant difference between either the BAO (0.08 ± 0.02 meq/kg/hr) or the MAO (0.90 ± 0.14 meq/kg/hr) in the PUD patients and the values obtained in NL children (p > 0.05). There was also no significant difference between the groups for either BAO or MAO when comparisons were made on a meq/M2/hr basis. Pre and post treatment BAO and MAO values in PUD patients were not statistically different (p > 0.5). In conclusion: 1) Since neither the BAO or the MAO in children correlated with weight, height, age or sex, gastric acid secretory data should be interpreted on a meq/kg/hr basis. 2) Gastric acid hypersecretion was not found in children with PUD either before or after treatment.
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Byrne, W., Euler, A. 523 GASTRIC ACID SECRETION IN CHILDREN: A COMPARISON BE-TWEEN NORMALS AND THOSE WITH PEPTIC ULCER DISEASE (PUD). Pediatr Res 15 (Suppl 4), 527 (1981). https://doi.org/10.1203/00006450-198104001-00536
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DOI: https://doi.org/10.1203/00006450-198104001-00536