Abstract
A.M., a male aged 7.7 years presented with rapid growth since the age of 5 years. His height was 151.1 cm, and weight 36.7 kg. There was no secondary sexual development. Investigation showed enlargement of the pituitary fossa, a slightly advanced bone age, elevated levels of plasma GH (30-70 mU/1) with no suppression after glucose. Plasma prolactin was also elevated (2000 mU/1) but pituitary function otherwise normal. Treatment with Bromocriptine (up to 20 mg/day) resulted in rapid suppression of prolactin but less rapid suppression on GH to near-normal. Treatment was associated with a fall in growth rate from 9.0 cm/year to 5.6 cm/year.
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Grant, D., Jackson, D. & Jones, J. Pituitary Gigantism: Apparent Response to Bromocriptine. Pediatr Res 15, 85 (1981). https://doi.org/10.1203/00006450-198101000-00084
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DOI: https://doi.org/10.1203/00006450-198101000-00084