Abstract
The relationships of serum (Se) to saliva (Sa) concentrations of Caffeine (Caf) and total methylxanthines (Mx) (Mx = Caf + Theophylline (Theo)) have been established in neonates treated with Caf for apnea (J.Pediatr.96:494,1980). Serum to Sa relationships derived with additional studies have been crossvalidated against the old data. The standard deviations (SD) and correlation coefficients (R) for the Se to Sa relationships are presented below. Data for Mx is presented because of Caf to Theo conversion in neonates.
From the high R values for both Caf and Mx it appears that the newly derived relationships crossvalidate well with the old data.
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Khanna, N., Somani, S., Miller, J. et al. 342 CROSSVALIDATION OF SERUM TO SALIVA RELATIONSHIPS OF CAFFEINE AND TOTAL METHYLXANTHINES IN NEONATES. Pediatr Res 15 (Suppl 4), 497 (1981). https://doi.org/10.1203/00006450-198104001-00353
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DOI: https://doi.org/10.1203/00006450-198104001-00353