Abstract
12 infants were treated for PPHN from 1978 to 1980; nine survived. We were able to evaluate 5 of 7 [xBW=2.1 kg, xGA=37 (32-40), x5m Apgar=7] infants now >6 months old, who are being followed by their referring pediatricians. Surviving infants suffered episodes of hypo and hyperoxia 5/5, hypotension 3/5, and hypo and hypercarbia 5/5. An electrocardiogram, vector-cardiogram, and echocardiogram, chest x-ray, arterial blood gas, ophthalmologic exam, computerized brain scan (CAT), Bayley Scale of Infant Development, and physical examination by a pediatric cardiologist were done on each patient. No child was completely normal. Abnormalities include evidence of residual or previously undiagnosed cardiopulmonary disease in 3/5, minor CAT scan abnormalities in 3/5, and severe abnormality in 1/5, developmental delay in two children, severe in one (DQ<50) and borderline (DQ=86) in another, and optic atrophy in one child. None had evidence of retrolental fibroplasia or bronchopulmonary dysplasia. We conclude that these salvaged babies constitute a very high risk population for ongoing difficulties, whose followup needs include expensive multidisciplinary testing and treatment. Organized followup for these children must be developed. PPHN should be an identified risk category for enrollment in state Crippled Children's funding programs.
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Drummond, W., Resnick, M., Keil, E. et al. 45 FOLLOW UP EVALUATION OF NEONATES TREATED WITH DRUGS AND HYPERVENTILATION FOR SEVERE PERSISTENT PULMONARY HYPERTENSION (PPHN). Pediatr Res 15 (Suppl 4), 447 (1981). https://doi.org/10.1203/00006450-198104001-00054
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DOI: https://doi.org/10.1203/00006450-198104001-00054