Abstract
Salicylates intoxication induces a lower blood glucose level than control in rats(74.80±6 vs 130.07±5.4 p 0.01). Slices from pancreas of intoxicated rats, secretes more insulin than controls when incubated in the presence of glucose (1.27±0.08vs 0.79±0.03,mug/mg w.t./30min:p 0.001). Sodium salicylate increase both phases of secretion induced by glucose (5.5 to 16.5mM) in the isolated perfused rat pancreas. The increment is not observed when 27.5 mM glucose in utilized. Puromycin,80 ug/ml has no effect on the action of sodium salicylate on the insulin secreted by glucose 5.5 and 16.5 mM. The results shown suggest that: a) sodium salicylate increases both phases of insulin secretion induced by glucose “in vitro” and “in vivo”; b) both, salicylate and glucose, cause insulin secretion by acting on the same compartment; c) the increased sensitivity of the beta cell to glucose, induced by salicylate, is unrelated to insulin synthesis; d) the effect of sodium salicilate en insulin secretion induced by glucose, could explain, at least in part, the hypoglycemia observed in the salicylate intoxication.
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Basabe, J., Bruno, L., Alvarez, E. et al. 91 SALICYLATE INTOXICATION AND INSULIN SECRETION: “IN VIVO” AND “IN VITRO” STUDIES. Pediatr Res 15, 198 (1981). https://doi.org/10.1203/00006450-198102000-00148
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DOI: https://doi.org/10.1203/00006450-198102000-00148