Abstract
Twenty-two Dutch Caucasoid families were ascertained for two or more children with IDM. The HLA-A, B, C and DR antigens and C4, BF, C2 and GLO polymorphisms were determined and the sera were screened for various autoimmune antibodies. We also determined a locally defined split of DR4 (LB4 and LB10). Fourteen families had two children affected, one three and one four (Group A). Six families had two children and one parent affected (Group B). The probands (first affected child per family) showed, after correction for the number of antigens tested, a significant increase in DR3 and DR4. However the increase in DR4 was due to an increase in LB4 alone and not to LB10. The decrease in DR2 was not significant.
The HLA-relationships between probands and siblings were:
The data suggest DR3 and DR4 (LB-4) are associated with increased susceptibility to IDM in the Netherlands. The haplotype assortments are compatible with a recessive mode of inheritance. More studies are in progress to determine the significance of the split of DR4 for the susceptibility to IDM.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bruining, G., de Jongh, B., Schuurman, R. et al. HLA-antigens in Familial Insulin Dependent Diabetes of childhood (IDD) in The Netherlands. Pediatr Res 15, 1566 (1981). https://doi.org/10.1203/00006450-198112000-00187
Issue Date:
DOI: https://doi.org/10.1203/00006450-198112000-00187