Abstract
Human serum contains an ultrafiltrable factor (350 < M.W. < 700) which stimulates sulphation activities of native, or purified somatomedin A of either small or high molecular weight. The factor is heat stable, resists protease hydrolysis but is destroyed by strong acidic hydrolysis. It is not extractible by chloroform. It restores somatomedin activities of conserved fractions and allows good conditions of bioassays of purified fractions. This factor is not a known amino-acid, a polyamine, vitamin A, zinc, T4 or T3. It stimulates somatomedin activity equally if added together with the somatomedin, or if added before (and removed) the adding of somatomedin.
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Heulin, M., Artur, M., Malaprade, D. et al. Evidence for the presence in human serum of an ultrafiltrable factor activating somatomedins. Pediatr Res 15, 1552 (1981). https://doi.org/10.1203/00006450-198112000-00105
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DOI: https://doi.org/10.1203/00006450-198112000-00105