Abstract
Summary: To study the effects of Group B β-hemolytic Streptococcus on the pulmonary circulation and lung fluid balance, live and heat-killed bacteria and their toxin were infused into an awake sheep lung-lymph preparation. In every case, the response was biphasic; there was an initial period of marked pulmonary hypertension and high flow of protein-poor lymph associated with tachypnea, chills, and fever. A second phase followed during which pulmonary vascular pressures returned to near baseline and remained stable, but lymph flow remained high. The changes seen in the initial phase resemble the previously reported response to mechanically increased pulmonary vascular pressure and suggest that the increase in fluid filtration is secondary to increased microvascular pressure. During the second phase after toxin infusion, the increase in lung lymph flow was paralleled by an increase in lymph protein clearance. This cannot be accounted for by the hemodynamic changes alone and suggests that the permeability of lung microvascular walls to protein was increased. It is concluded that group B β-hemolytic streptococcal toxin in the sheep model causes pulmonary hypertension and increased pulmonary vascular permeability.
Speculation: The effects caused by group G β-hemolytic Streptococcus toxin on the pulmonary circulation may be relevant to the pathogenesis of the respiratory distress and shock seen in newborns with this infection. Further understanding of the effects of this toxin could provide means for therapeutic intervention.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rojas, J., Green, R., Hellerqvist, C. et al. Studies on Group B β-Hemolytic Streptococcus. II. Effects on Pulmonary Hemodynamics and Vascular Permeability in Unanesthetized Sheep. Pediatr Res 15, 899–904 (1981). https://doi.org/10.1203/00006450-198106000-00003
Issue Date:
DOI: https://doi.org/10.1203/00006450-198106000-00003
Keywords
This article is cited by
-
Group B Streptococcus, phospholipids and pulmonary hypertension
Journal of Perinatology (2011)
-
Soluble E-selectin in cancer patients as a marker of the therapeutic efficacy of CM101, a tumor-inhibiting anti-neovascularization agent, evaluated in phase I clinical trial
Journal of Cancer Research and Clinical Oncology (1997)
-
Acute inflammatory changes in subcutaneous microtumors in the ears of mice induced by intravenous CM101 (GBS toxin)
Journal of Cancer Research and Clinical Oncology (1996)
-
CM101, a polysaccharide antitumor agent, does not inhibit wound healing in murine models
Journal of Cancer Research and Clinical Oncology (1995)
-
Antitumor effects of GBS toxin: a polysaccharide exotoxin from group B?-hemolytic streptococcus
Journal of Cancer Research and Clinical Oncology (1993)