Abstract
In order to evaluate the cardiorespiratory effects of changes in the duration of the positive-pressure (DPP) on the neonates requiring mechanical ventilation, 6 infants (2 with meconium aspiration and 4 with bronchopulmonary dysplasia) were studied. Their (mean ± S.E.) B.wt.= 1985 ± 352 gms. and GA =33 ± 1.8 wks. Arterial blood pressure (ABP), central venous pressure (CVP), blood gases and M-mode echocardiograms were obtained prior to and 10 minutes after changing DPP by 200 milliseconds while maintaining the same mean airway pressure. This was achieved by adjusting the respirator rate and the peak inspiratory pressure. There were no significant changes in ABP, CVP, PaO2, pH, LA/AA, LVIDd and LPEP/LVET, whereas, the RPEP/RVET increased in every instance after an increase in DPP (0.31 ± 0.04 versus 0.37 ± 0.05. P <0.01). This implicates an increase in pulmonary arterial pressure as a direct result of longer DPP. The results of this study indicate a relatively shorter DPP and faster ventilator rate is the more appropriate setting in order to avoid worsening of an existing pulmonary hypertension in term infants with meconium aspiration and premature infants after the acute stage of HMD.
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Siassi, B., Arce, P., Cabal, L. et al. 1725 CARDIORESPIRATORY EFFECTS OF CHANGES IN THE DURATION OF POSITIVE PRESSURE IN THE NEWBORN INFANT ON MECHANICAL VENTILATORS. Pediatr Res 15 (Suppl 4), 731 (1981). https://doi.org/10.1203/00006450-198104001-01744
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DOI: https://doi.org/10.1203/00006450-198104001-01744