1572 CENTRAL NERVOUS SYSTEM LACTATE PRODUCTION AND CLEARANCE IN NEWBORN PUPPIES FOLLOWING 15 AND 30 MINUTES OF ASPHYXIA

Abstract

Recent studies have suggested that CSF lactate may be useful in assessing perinatal asphyxia. We studied lactate metabolism in spontaneously breathing newborn beagle puppies lightly anesthetized with ≤ 0.5% halothane and nitrous oxide. Lactate was measured in plasma, brain tissue and CSF following 15 and 30 minutes of asphyxia (FiO2 2-5%; FiCO2 7-8%) and 1 hour recovery. Experimental groups were compared to appropriate controls.

Plasma and brain tissue lactate rose to similar levels following asphyxia. Clearance of lactate by 1 hour was also similar for plasma and brain. CSF lactate rose to lower levels but was not cleared appreciably by 1 hour for either the 15 or 30 minute asphyxia group. The delayed clearance of CSF lactate may be useful clinically in assessing perinatal asphyxia. (Supported by HL 18351 and *RCDA HL 00364)

Author information

Rights and permissions

Reprints and Permissions

About this article