Abstract
The presence of low-level tissue directed antibodies (AAb's) and immune complexes (IC) were determined in 12 MCNS and 5 mesangial proliferative glomerulonephritis (MesPGN) patients with biopsy proven disease. The AAb's were detected by immunofluor-escence (IF) against human cadaveric tissues and the IC detected by 3 different methods and isolated by polyethylene glycol precipitation/sedimentation. The isolated antibodies from the IC were also tested by IF for AAb activity against the same tissue antigen battery. The presence of such AAb activity was demonstrated in 8/12 MCNS and in all of the MesPGN sera. In the MCNS group 7/8 of the AAb positive sera also contained IC with corresponding AAb activity (2/7 directed against smooth muscle antigens and 5/7 directed against kidney tubular microsomes). The MesPGN group all reacted against kidney basement membrane antigens but no other tissue antigen. Of these 3/5 also demonstrated the presence of IC which contained AAb reactive with the same kidney antigen.
The presence of such AAb's and their formation of IC indicates that these antibodies may have a functional role in the initial immunological insult to the kidney.
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Phillips, T., Tina, L., Jose, P. et al. 1529 MINIMAL CHANGE NEPHROTIC SYNDROME (MCNS): AN AUTOIMMUNE DISEASE?. Pediatr Res 15 (Suppl 4), 698 (1981). https://doi.org/10.1203/00006450-198104001-01552
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DOI: https://doi.org/10.1203/00006450-198104001-01552